The most efficacious level

I have a naive trust in the universe......that at some level it all makes sense, and we can get glimpses of that sense if we try.”
......Mihaly Csikszentmihalyi (as quoted in the little book of flow)

At which level does the universe make sense? It depends. Different parts make sense at different levels. You don't use particle physics to understand human behavior, the level of complexity would make it impossible to see why certain quarks could explain why I am in a bad mood. But you could use chemistry to explain it- neurotransmitter levels surely appear to be highly correlated to mood. Maybe it's something more circumstantial, like doing the dishes after midnight on a Saturday that provides the most sense making. Or an ethernet switch with an overly noisy fan. Things that make my flow static. Then again, sometimes you really can't point to the circumstances, but the chemistry is still there. Serotonin is low, sadness is high. So is the chemistry the better explanation, or is the universe the circumstance?